Methylcobalamin (Vitamin B₁₂): Precision Neuro‑Support for Peripheral Neuropathy

Methylcobalamin (Vitamin B₁₂): Precision Neuro‑Support for Peripheral Neuropathy

ReliefNow uses Methylcobalamin (MeCbl)—the active, methylated form of vitamin B₁₂—for direct support of nerve health and neuroregeneration.

Mechanism of Action

Clinical Evidence

  • A major systematic review found that combination treatment including MeCbl significantly improved clinical efficacy and nerve conduction in peripheral neuropathy, though standalone results were less consistentScienceDirect+5PubMed+5PMC+5.

  • A 24‑week open‑label trial of 1500 μg/day MeCbl in diabetic neuropathy patients showed significant symptom improvement with no adverse outcomes SCIRP.

  • And a randomized clinical trial with ultra‑high‑dose methylcobalamin demonstrated a 43% reduction in deterioration over time in early neuropathy JAMA Network.

  • One-year oral MeCbl (1 mg/day) improved neurophysiological markers, sudomotor function, pain scores, and quality of life—though some measures showed mixed results MDPI.

Benefits

  • Boosts nerve signal transmission and conduction

  • Supports vascular-neural health via homocysteine reduction

  • May reduce pain and numbness caused by neuropathy

Takeaway
Methylcobalamin in ReliefNow’s formula is evidence‑backed for supporting nerve repair and improving symptoms in diabetic and other forms of peripheral neuropathy.

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