ReliefNow uses Methylcobalamin (MeCbl)—the active, methylated form of vitamin B₁₂—for direct support of nerve health and neuroregeneration.
Mechanism of Action
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MeCbl supports myelin sheath repair, nerve conduction velocity (NCV), and neuron resilience by aiding methylation pathways and reducing homocysteine-induced toxicity WikipediaPubMed+7Gene Food+7ScienceDirect+7.
Clinical Evidence
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A major systematic review found that combination treatment including MeCbl significantly improved clinical efficacy and nerve conduction in peripheral neuropathy, though standalone results were less consistentScienceDirect+5PubMed+5PMC+5.
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A 24‑week open‑label trial of 1500 μg/day MeCbl in diabetic neuropathy patients showed significant symptom improvement with no adverse outcomes SCIRP.
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And a randomized clinical trial with ultra‑high‑dose methylcobalamin demonstrated a 43% reduction in deterioration over time in early neuropathy JAMA Network.
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One-year oral MeCbl (1 mg/day) improved neurophysiological markers, sudomotor function, pain scores, and quality of life—though some measures showed mixed results MDPI.
Benefits
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Boosts nerve signal transmission and conduction
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Supports vascular-neural health via homocysteine reduction
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May reduce pain and numbness caused by neuropathy
Takeaway
Methylcobalamin in ReliefNow’s formula is evidence‑backed for supporting nerve repair and improving symptoms in diabetic and other forms of peripheral neuropathy.